IMBIO® Products

IMB’s lead product is EkobiTM 500 Embolization Microspheres, is a first-in-class biodegradable embolic agent that is detectable by ultrasound for the treatment of malignant and non-malignant vascularized tumors and enlarged prostates (benign prostatic hypertrophy/hyperplasia BPH).  Examples of vascularised tumors include hepatocellular carcinoma (HCC; liver cancer), renal cell carcinoma (RCC; kidney cancer), and uterine fibroids.

 

Ekobi 500 is delivered through a catheter into the blood vessels that feed a target tissue and selectively block the tissue’s blood supply.  The target tissue is either destroyed or devitalized, resulting in a therapeutic benefit. 

 

Unlike other embolic agents that are permanent implants and remain in the patient’s body for life, Ekobi 500 is biodegradable The Ekobi 500 microspheres slowly degrade and are completely eliminated from the body in 4-6 months.  The microspheres are made from poly(lactic-co-glycolic acid) or PLGA, an established safe polymer, which is widely used in medical devices and drug products.   The PLGA simply degrades into carbon dioxide and water. 

 

Ekobi 500 microspheres are hyperechoic, meaning they are visible by ultrasound.  Post-treatment the microspheres are easily detected using minimally invasive ultrasound.

 

Ekobi 500 is currently available for sale in Canada and USA.  Microspheres are available in a variety of calibrated sizes, ranging from 40 µm to 800 µm.

 

Product Code

Particle Size

Application

OCL 501

40 – 100 µm

Embolization of distal micro-vasculature.  Suitable for use with microcatheters.

OCL 503P

150 – 180 µm

Embolization of arteries and arterioles 0.2mm to 2 mm in diameter.  Suitable for use with 2.4F microcatheters or larger.

OCL 503L

180 – 212 µm

Embolization of arteries and arterioles 0.2mm to 2 mm in diameter.  Suitable for use with 2.8F microcatheters or larger.

OCL 504

212 – 300 µm

Embolization of arteries and arterioles 0.4mm to 4 mm.  Suitable for use with 4F catheters or larger.

OCL 505

300 – 425 µm

Embolization of arteries and arterioles 0.4mm to 4 mm.  Suitable for use with 4F catheters or larger.

OCL 507

500 – 800 µm

Embolization of arteries greater than 1 mm in diameter.  Suitable for use with 5F catheters or larger.

 

Product Specifications:

  • Sterile
  • Pyrogen Free
  • Dry, Free-flowing powder provided in a 20 mL glass vial
  • Single Patient Use

 

Indications:

 

Canada: Embolization of target tissues including hypervascularized tumors and enlarged prostates due to benign prostatic hypertrophy/hyperplasia.

 

USA: An artificial embolization device for the treatment of unresectable/inoperable hypervascularized tumors.

 

Note: The safety and effectiveness of Ekobi 500 has not been established in neurological applications or in the treatment of uterine fibroids.

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